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David Villa and Andres Iniesta scored for Spain, while Rodrigo Millar was on target for South Americans. It is worth to note that, David Villa scored the 100th goal of 2010 FIFA World Cup.
In other match of the Group, Switzerland failed to grab the win they required to reach the World Cup last 16 after playing 0-0 draw with Honduras.
Chile will meet Brazil in the last 16, while Spain will face Portugal on Monday evening.