Zaynitdin Tadjiyev scored a brace in the 10th and 38th minute while Odil Ahmedov and Sanat Shikhov added a goal each for Viktor Djalilov’s team.
The ACL ever-presents are leading the Group A standings with 10 points from four games, followed by Saudi Arabia’s Al Hilal on 8 whom they will face away in the last group game on May 20.
The victory helped Pakhtakor keep the second place in the standings with 20 points from eight rounds, four less than leaders Bunyodkor.
In other games, Lokomotive beat Khorezm 2-0, Almalik sidelined Mashal by the same scoreline, Andijan overcame Kyzylkum 2-1 and Navabhor brushed aside Metallurg 3-0.
STANDINGS: 1. Bunyodkor 24, 2. Pakhtakor 20, 3. Nasaf 16, 4. Almalik 16, 5. Lokomotive 14.