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Denis Istomin stunned Ferrer in straight sets - 6:4 and 6:3. In the first set, Istomin broke Ferrer in the first game and held his nerve to clinch the set.
In the second set, Ferrer started strong and broke Istomin to claim a 3:0 lead, but world number 51 won next six games to advance to the fourth round.
The match lasted one hour and fifteen minutes. Both players served five aces each. Ferrer made three double faults compared to none by Istomin.
In next round, Denis Istomin will face Juan Martín Del Potro of Argentina, who is currently world number nine.